- Secondary amyloidosis complication of Crohn disease treated with infliximab.
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Min Joo Song, Hyo Sang Kim, Soyoung Park, Jaekyung Cheon, Sojung Park, Ji Young Yang, Su Kil Park
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Yeungnam Univ J Med. 2015;32(2):102-105. Published online December 31, 2015
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DOI: https://doi.org/10.12701/yujm.2015.32.2.102
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 Abstract
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- Secondary systemic (AA) amyloidosis is a severe complication of progressed Crohn disease (CD) characterized by the deposition of amyloid A in body organs and tissues. Various therapeutic approaches have been recommended, however there is still no effective treatment. Recently, several case reports have demonstrated the effects of anti-tumor necrosis factor-alpha therapy in patients with AA amyloidosis associated with CD. We report on a 35-year-old female patient with CD complicated by AA amyloidosis in the gastrointestinal tract and renal involvement, who was treated with infliximab. The infliximab therapy improved the gastrointestinal symptoms and decreased the serum creatinine.
- Malignant mesothelioma mistaken for tuberculous pleurisy.
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Ji Young Yang, Min Joo Song, So Jung Park, Jaekyung Cheon, Jung Wan Yoo, Chang Min Choi, Yong Hee Kim
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Yeungnam Univ J Med. 2015;32(1):50-54. Published online June 30, 2015
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DOI: https://doi.org/10.12701/yujm.2015.32.1.50
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Abstract
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- Malignant mesothelioma is a common, primary tumor that can invade pleura, and is associated with previous exposure to asbestos. However, it poses considerable difficulties regarding its diagnosis and treatment, and thus, accurate history taking with respect to exposure to asbestos, and radiologic and pathologic examinations are essential. In addition, the involvement of a multidisciplinary team is recommended in order to ensure prompt and appropriate management using a framework based on radiotherapy, chemotherapy, surgery, and symptom palliation with end-of-life care. Because lymphocyte-dominant, exudative pleural effusion can occur in malignant mesothelioma, adenosine deaminase values may be elevated, which could be mistaken for tuberculous pleurisy, and lead to an incorrect diagnosis and suboptimal treatment. The authors describe a case of malignant mesothelioma initially misdiagnosed as tuberculous pleurisy. As evidenced by the described case, malignant mesothelioma should be considered during the differential diagnosis of patients with lymphocyte-dominant, exudative pleural effusion with a pleural lung lesion.
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Yeungnam University College of Medicine
